According to reports from the Centers for Disease Control and Prevention (CDC), more than 5 million people are afflicted with heart failure related diseases, and about half of these will die within the span of 5 years.
But, good news: innovative scientists from the Indiana University School of Medicine, led by Dr. Ching-Pin Chang have been able to single out a relatively unknown molecule until recently which shows high potential in preventing or perhaps curing the said heart condition.
In an experiment which involved mice with heart failure as experimental subjects, the scientists were able to discover the molecule Myheart. By increasing the levels of this molecule in afflicted mice, they were able to decrease the progression of complicating heart problems into a stop.
The Myheart molecule is a myosin heavy-chain-associated RNA transcript, a non-coding RNA which has a direct effect on the BRG1 protein, which is subsequently responsible for the development and growth of the heart in fetuses. According to lead scientist Dr. Chang, "I think of Myheart as a molecular crowbar that pries BRG1 off the genomic DNA and prevents it from manipulating genetic ability." It may be thought of having the molecule simply stop the effects caused by increased BRG1 especially in specimens having difficulty pumping oxygenated blood throughout the body, according to a press release statement.
With the preliminary method of transfer technology of Myheart to the mice specimen, they are now on the next step in trying to mimic or duplicate for humans. Since the Myheart molecule is quite large as a molecule to be used as a treatment drug for human physiology, scientists are now looking for means to make a smaller molecular version to make it fully utilizable for humans.
Until such a time that human Myheart medication is achieved, scientists and doctors are keen on advising individuals, especially those who are obese, to prioritize losing excess weight and having a proper balance of diet and exercise to lessen the complications leading to heart failure.
